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针对抗药性结直肠癌,使用apigenin纳米架构进行向

Pouya Goleij¹, Saeid Ferdousmakan², Mohammad Amin Khazeei Tabari³

¹USERN Office, Kermanshah University of Medical Sciences, Kermanshah 6715847141, Iran; Department of Genetics, Faculty of Biology, Sana Institute of Higher Education, Sari 4816118761, Iran.

Translational oncology

|June 25, 2025

概括

基因纳米架构在克服结直肠癌 (CRC) 中的耐药性方面表现有前途. 这些配方增强了阿比基宁的输送,增加了对抗抗性CRC细胞的疗效,并提供了新的治疗策略.

科学领域:

在瘤学瘤学.
纳米技术纳米技术
药理学药理学是指药理学的学科.

背景情况:

耐药性是结直肠癌 (CRC) 治疗的一个主要挑战,导致高死亡率.
传统治疗CRC的局限性包括毒性和多药耐药性 (MDR).
作为一种天然的黄类化合物,apigenin正在研究其对抗耐药性CRC的潜力.

研究的目的:

审查和评价使用原蛋白载荷纳米架构来克服CRC中药物耐药性的使用.
检查通过纳米载体传递的阿皮基宁的疗效,如PLGA纳米粒子,脂质聚合物混合纳米粒子和脂质体.
评估原蛋白对细胞机制,瘤微环境和化学疗法的协同效应的影响.

主要方法:

对用于治疗CRC的apigenin载荷纳米架构进行当前研究的综述.
纳米载体介导输送系统 (PLGA纳米粒子,脂质聚合物混合纳米粒子,脂质体) 的分析.
评估阿皮基宁对抗药性CRC细胞的影响,包括细胞吸收,细胞亡,细胞循环停止和途径抑制 (PI3K/Akt/mTOR).

主要成果:

原蛋白纳米架构提高了生物可用性,向性传递和持续释放的原蛋白.
载有阿皮基因的纳米粒子增强细胞吸收,克服药物排泄,并诱导耐药CRC细胞的亡.
原蛋白抑制增殖,阻止细胞循环,抑制瘤性途径,并破坏血管生成和炎症.

结论:

原蛋白纳米架构是通过克服药物耐药性来提高CRC治疗结果的有效策略.
原蛋白作为一种化疗敏感剂,并显示出对CRC的组合疗法的潜力.
为了改善CRC治疗,需要进一步开发apigenin纳米架构的临床研究.

关键词:

它们的原生素是apigenin.化学抗药性化学抗药性是一种抗药性.结肠直肠癌是一种癌症.多种药物耐药性耐多种药物耐药性纳米颗粒纳米颗粒

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