相关实验视频

Updated: Sep 18, 2025

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

新迈龙注射通过MDH2/OAA通路改善了多克索鲁比诱导的心脏毒性

Sa Liu¹, Suifen Xie¹, Taoli Sun²

¹Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Institute of Clinical Pharmacy, Central South University, Changsha, Hunan 410011, China.

Phytomedicine : international journal of phytotherapy and phytopharmacology

|June 25, 2025

概括

新mailong注射 (XML) 通过上调MDH2.2来预防多克索鲁比诱导的心脏毒性 (DIC). 这种机制增强了ATP的产生,并抑制了亡,为DIC的预防和治疗提供了新的策略.

科学领域:

心血管药理学心血管药理学
瘤学药物安全药物安全
毒性的分子机制.

背景情况:

多克索鲁比 (Dox) 是一种重要的抗癌药物,但其使用受到心脏毒性 (DIC) 的限制.
来自美国的新mailong注射 (XML) 治疗心力衰竭,但其对DIC的影响尚不清楚.

研究的目的:

调查XML对DIC的保护作用.
为了阐明XML心脏保护作用背后的分子机制.

主要方法:

建立了体外 (H9c2细胞) 和体内 (C57BL/6小鼠) 的DIC.模型.
利用HPLC-MS,网络药理学和代谢学来识别关键目标和途径.
进行实验验证,以确认确定目标的作用.

主要成果:

在细胞和动物模型中,XML减少了Dox诱导的亡.
在XML中确定了30种活性化合物和179个与XML和DIC相关的共同向基因.
代谢学揭示了氧化酸盐 (OAA) 代谢和TCA循环的丰富,突出了MDH2作为核心目标.
XML上调调节了MDH2和OAA,逆转了Dox诱导的心脏功能障碍和ATP耗尽;抑制MDH2取消了XML的保护作用.

结论:

通过上调MDH2的调节,XML有效地减轻DIC,从而增强ATP生成并抑制细胞亡.
这项研究提供了新的见解和治疗策略,用于预防和治疗多克索鲁比诱导的心脏毒性.

关键词:

这就是ATPATPATP ATP.德克索鲁比辛诱导的心脏毒性在MDH2/OAAAA中使用.代谢过程中的代谢.网络药理学网络药理学新迈龙注射的注射

更多相关视频

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish

Published on: June 7, 2018

Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model

Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model

Published on: January 21, 2018

相关概念视频

Heart Failure Drugs: Inotropic Agents

Heart Failure Drugs: Inotropic Agents

Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...