在老年人中,他类药物使用和脑卒中后之间的关联:一项嵌套病例对照研究
R Grace Couper1, Tresah C Antaya1, Brooke Carter2
1Neuroepidemiology Research Unit, Department of Clinical Neurological Sciences, Western University, 1151 Richmond St, HSA-200, London, Ontario N6A 3K7, Canada; Epilepsy Program, Department of Clinical Neurological Sciences, Western University, 339 Windermere Road, London, Ontario N6A 5A5, Canada; Department of Clinical Neurological Sciences, Western University, 339 Windermere Road, London, Ontario N6A 5A5, Canada.
Epilepsy research
|June 25, 2025
概括
在中风后使用他类药物并没有增加的总体风险. 然而,阿托瓦斯塔丁的使用与女性中风后 (PSE) 的风险更高有关,这需要进一步调查.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 脑卒中后 (PSE) 是继缺血性脑卒中后的一种严重并发症.
- 静止剂治疗通常在缺血性中风后进行,以减少心血管风险.
- 类药物使用与PSE风险之间的关联以及潜在的基于性别的差异需要澄清.
研究的目的:
- 估计中风后使用他类药物与患PSE的风险之间的关联.
- 评估生物性别是否会改变他类药物使用和PSE之间的关系.
- 调查特定的他类药物特征和其他风险因素对PSE的影响.
主要方法:
- 基于人口的嵌套病例控制研究,使用加拿大安大略省链接的卫生行政数据.
- 包括在2007年4月至2017年3月期间因缺血性中风接受治疗的65岁以上居民.
- 病例的匹配 (n=1009) 与最多10个对照 (n=6522) 根据年龄,性别和月份;多变量条件后勤回归分析.
主要成果:
- 总体而言,他类药物的使用与增加PSE风险没有显著关联 (IRR = 1.17;95% CI 0.95-1.43).
- 性别并没有显著改变他类药物使用和PSE之间的关联 (p=0.08).
- 阿托瓦斯塔丁的使用与特别在女性中增加PSE风险有关 (IRR=1.26;95%CI1.02-1.56).
结论:
- 一般来说,中风后使用他类药物似乎不会增加患的风险.
- 虽然性别没有改变整体关联,但由于女性PSE风险可能增加,阿托瓦斯塔丁的使用需要进一步调查.
- 需要进一步研究,以阐明阿托瓦斯塔丁与女性PSE之间观察到的关联背后的特定机制.
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