通过元分析探索人类毒素菌血清流行的全球趋势
Pinaki Prasad Sengupta1, Siju Susan Jacob1, Kuralayanapalya Puttahonnappa Suresh1
1ICAR- National Institute of Veterinary Epidemiology and Disease Informatics, Yelahanka, Bengaluru, 560064, Karnataka, India.
Experimental parasitology
|June 25, 2025
概括
全球毒素菌血清流行率为31%,澳大利亚,南美和非洲的发病率更高. 这种传染病趋势呈增长趋势,影响全球公共卫生规划.
科学领域:
- 全球健康 全球健康
- 传染性疾病 传染性疾病
- 寄生虫学的寄生虫学
背景情况:
- 毒素菌引起的毒素菌对孕妇和免疫力低下的人来说存在重大风险.
- 了解全球传染病患病率对于公共卫生战略和资源配置至关重要.
研究的目的:
- 进行全面的系统审查和对全球人类毒素菌病血清流行率的元分析.
- 综合来自众多研究的数据,以估计聚合的血清流行率并确定区域差异.
主要方法:
- 在PubMed,ScienceDirect和谷歌学者 (1959-2020) 中进行系统的文献搜索.
- 包括320项研究,包括来自113个国家的658172名个人.
- 进行元分析以估计聚合血清流行率,并根据地区,时间,国家和诊断方法进行子组分析.
主要成果:
- 据估计,毒素的全球血清流行率为31% (95% CI: 28-34%),具有显著的异质性.
- 在澳大利亚 (54%),南美 (45%) 和非洲 (42%) 观察到的患病率最高;在亚洲 (25%) 较低.
- 观察到时间上升趋势,在2011-2020年间达到34%,基于IFAT (41%) 等诊断方法的变化.
结论:
- 这项研究提供了一个全面的综合全球毒素菌血清流行,突出显著的区域差异.
- 研究结果强调需要有针对性的公共卫生干预措施,特别是在高患病率地区.
- 这些数据作为全球卫生规划和未来对*Toxoplasma gondii*感染的研究的关键参考.
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