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在真正的自然与激素替代周期中单个欧卵性冷胚胎移植的成本效益

Laura Marqueta Marques¹, Astrid Van Muylder², Maud Brijs²

¹ART Fertility Clinics, IVF Department, Abu Dhabi, United Arab Emirates.

Fertility and sterility

|June 25, 2025

概括

与激素替代疗法 (HRT) 相比,单胞胎冷胚胎移植 (seFET) 的真正自然循环 (tNC) 协议显示出更高的活产率和更低的流产率. 虽然tNC每周期的成本更高,但其效率的提高可能会根据支付意愿提供更好的价值.

科学领域:

生殖内分泌学生殖内分泌学
在体外受精过程中受精.
卫生经济学卫生经济学

背景情况:

子宫内膜的准备对于成功的冷胚胎移植 (FET) 至关重要.
真正的自然循环 (tNC) 和激素替代疗法 (HRT) 是用于单个胚胎胚胎移植 (seFET) 的子宫内膜制备的常见方案.
评估不同子宫内膜制备方案的成本效益对于优化患者护理和资源配置至关重要.

研究的目的:

为了比较真实自然循环 (tNC) 与单个胚胎胚胎转移 (seFET) 中的子宫内膜制备激素替代疗法 (HRT) 的成本效益.

主要方法:

在2017年4月至2021年9月期间,对1188名接受seFET的妇女进行了回顾性队列研究.
在tNC和HRT协议之间比较临床结果 (怀孕率,流产率,活产率) 和治疗成本.
计算增量成本效益比率 (ICER) 和敏感性分析以确定成本效益值.

主要成果:

在tNC (63.8%) 和HRT (64.5%) 之间的怀孕率没有显著差异.
与HRT相比,tNC显示出明显较低的流产率 (10.3%与18.9%) 和较高的活产率 (53.0%与44.9%).
每个周期的平均成本对于tNC (US$2,540) 比HRT (US$1,991) 高,对于tNC,每次额外活产的ICER为US$7,486.

结论:

真正自然循环 (tNC) 协议为seFET提供了更好的临床有效性,主要是由于流产率降低.
激素替代疗法 (HRT) 与每个周期的前期成本较低有关.
付款人必须在选择seFET的最佳子宫内膜制备协议时考虑他们愿意支付活产的费用,以确保获得最佳价值.

关键词:

在ICER中,您可以使用ICER.一个单体幼体冷胚胎转移.经济效益性经济效益性荷尔蒙替代疗法循环疗法自然循环中的自然循环.

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