在丹麦艾滋病毒感染者中结核病后患癌症的风险:全国基于人口的队列研究
Christian Kraef1, Lars Haukali Omland1, Anders Porskrog2
1Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
The Journal of infectious diseases
|June 25, 2025
概括
艾滋病毒和结核病 (结核病) 患者不会面临长期增加的癌症风险. 对于这一群体,建议继续进行标准癌症查.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 人类免疫缺陷病毒 (HIV) 感染的个人在结核病 (TB) 感染后长期患癌症的风险尚未得到充分确立.
- 了解这种风险对于指导艾滋病毒感染者的临床管理和监测策略至关重要.
研究的目的:
- 为了评估结核病病史与随后的癌症风险在全国HIV感染者队列之间的关联.
- 确定结核病诊断是否会影响艾滋病毒阳性人群中的整体癌症发病率或特定癌症类型.
主要方法:
- 基于人口的队列研究使用来自丹麦艾滋病毒队列研究 (1995-2020) 的数据进行.
- 结核病和癌症的诊断是通过国家登记处确定的.
- 发病率和调整后的发病率比率 (aIRRs) 使用波桑回归计算,控制时间变化的CD4计数,年龄,性别和查尔森并发症指数 (CCI).
主要成果:
- 这项研究包括6135名艾滋病毒感染者,319人有结核病史.
- 在62,878个人年的随访中,诊断出451种癌症.
- 在结核病发生后,没有观察到整体癌症风险的显著增加 (aIRR: 1.1,95% CI: 0.7-1.8),包括肺癌 (aIRR: 1.7,95% CI: 0.5-5.5).
结论:
- 在一个大型的全国性队列中,艾滋病毒感染者的结核病与长期癌症风险的增加无关.
- 这些发现表明,目前针对艾滋病毒和结核病患者的标准化癌症监测协议应该继续不进行修改.
关键词:
艾滋病 艾滋病 艾滋病是什么?癌症 癌症 癌症 癌症丹麦 丹麦 丹麦 丹麦 丹麦艾滋病病毒 艾滋病病毒 艾滋病病毒肺癌 肺癌 是 一种 肺癌.这就是为什么TBTBTBTB队列研究是一项队列研究.基于人口的基于人口的.更多相关视频
23:06The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
Published on: August 11, 2008
19.2K
07:21Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment
Published on: June 23, 2019
21.4K
相关概念视频
Pulmonary Tuberculosis I
335
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
335
Pulmonary Tuberculosis IV
209
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
209
Pulmonary Tuberculosis II
387
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
387
Pulmonary Tuberculosis III
458
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
458
Cancer Prevention
6.3K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.3K
Pulmonary Tuberculosis V
249
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
249
