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慢性复杂区域性疼痛综合征中运动皮层刺激性增加

Jukka Vanhanen¹, Janne Nordberg², Janika Paavola³

¹BioMag Laboratory, HUS Diagnostic Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland; HUS Diagnostic Center, Clinical Neurophysiology, Clinical Neurosciences, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

|June 25, 2025

概括

复杂区域性疼痛综合征 (CRPS) 显示运动皮层刺激性增加. 这项研究没有发现慢性CRPS患者半球之间皮层内抑制或促进的差异.

科学领域:

神经科学是一个神经科学.
疼痛医学医学疼痛医学
发动机控制器的控制器

背景情况:

复杂区域性疼痛综合征 (CRPS) 涉及复杂的神经机制.
在CRPS中关于皮质脊髓刺激性和皮质运动表现的先前研究已经产生了不一致的结果.

研究的目的:

在CRPS类型I和II中描述皮质脊髓刺激性和皮质运动表现.
澄清关于CRPS中这些神经机制的先前研究中的不一致性.

主要方法:

59名CRPS患者 (I型和II型) 和23名健康对照人接受了跨磁刺激 (TMS) 和配对脉冲TMS.
评估包括静止运动值 (RMT),运动唤起潜力 (MEP) 幅度/延迟,短间隔皮质内抑制 (SICI) 和皮质内促进 (ICF).
在初级运动皮质 (M1) 的手部皮质表现区域也被双边评估.

主要成果:

与健康受试者相比,CRPS患者表现出较低的RMT,较高的MEP幅度和较低的ICF.
在CRPS患者中没有观察到SICI或ICF的显著半球间差异.
较高的疼痛强度与双边ICF增加和未受影响手部较小的运动代表区域相关.

结论:

该研究表明,与对照组相比,CRPS患者的运动皮层刺激性增加.
慢性CRPS似乎不涉及SICI或ICF的半球间不对称性.
这些发现提供了对慢性CRPS中皮质内抑制,促进和皮质脊髓刺激性的详细了解.

关键词:

在CRPS中,我们可以使用CRPS.复杂的区域性疼痛综合征运动皮层的运动皮层.配对脉冲TMS的使用情况.在TMSMS中使用.通过骨磁刺激来进行磁性刺激.

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相关概念视频

Somatosensation

Somatosensation

The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.