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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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新辅助治疗后化减少预测了侵入性瘤反应,但没有完全消除DCIS:系统性审查和元分析.

Noam Weiner1, Yaron Niv2, Eran Sharon1

  • 1Breast Surgery Unit, Department of Surgery, Rabin Medical Center-Beilinson Hospital, Petach Tikva, Israel; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Clinical breast cancer
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概括

经过新辅助治疗后乳腺癌化的减少显著预测了病理完整反应. 这一发现可能有助于指导治疗后的手术规划.

关键词:
乳腺癌 乳腺癌是什么?乳房成像检查 乳房成像检查微化是一种微化.新辅助性全身治疗新辅助性全身治疗.病理学完整的反应反应.

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科学领域:

  • 在瘤学瘤学.
  • 放射学 放射学是一门学科.
  • 病理学 病理学 病理学

背景情况:

  • 乳腺癌化的变化与治疗反应之间的关系尚不清楚.
  • 新辅助治疗旨在在手术前缩小瘤,评估反应至关重要.

研究的目的:

  • 系统地审查和元分析评估乳腺癌中新辅助治疗后化变化和病理完整反应 (pCR) 之间的关联的研究.

主要方法:

  • 在PubMed和EMBASE系统地搜索相关的英语研究的文献.
  • 使用随机效应模型进行元分析,以计算聚合赔率比率和置信区间.
  • 评估研究异质性,出版偏见和质量.

主要成果:

  • 包括8项涉及707名患者的研究. 新辅助治疗后化减少与实现pCR的几率显著增加有关 (OR=1.691,p<0.001).
  • 亚组分析证实了下降与没有下降的显著性 (OR=2.045,p=0.004).
  • 当在pCR定义中允许残留导管癌 in situ (DCIS) 时,这种关联仍然显著 (OR=2.196,p<0.001).

结论:

  • 在新辅助疗法后,乳腺癌化的减少是PCR的强烈预测因素.
  • 化变化可能作为额外的成像生物标志物,以帮助在新辅助治疗后的手术规划.