一个随机对照试验的艾滋病毒暴露前预防措施在急诊室 (PrEPPED) 提供
Ethan Cowan1, Erick Eiting2, Clare O'Brien-Lambert1
1Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Emergency Medicine, Rutgers New Jersey Medical School, Newark, New Jersey.
The Journal of emergency medicine
|June 25, 2025
概括
与转诊相比,急诊室的暴露前预防 (PrEP) 启动并没有增加使用率. 尽管患者对预防艾滋病毒查的满意度很高,但意识不足等障碍仍然存在.
科学领域:
- 公共卫生 公共卫生
- 预防传染病 预防传染病
- 紧急医疗 紧急医疗
背景情况:
- 口服暴露前预防 (PrEP) 是有效的预防艾滋病毒,但未得到充分利用.
- 紧急服务部门 (EDs) 向艾滋病毒感染风险较高的人群提供服务.
- 基于ED的PrEP启动面临可行性问题.
研究的目的:
- 评估ED中立即启动PrEP (iPrEP) 与转诊门诊启动的情况.
- 为了确定基于ED的iPrEP对90天后PrEP使用的影响.
主要方法:
- 试验性随机对照试验 (RCT) 将iPrEP在ED中与28天起始包与转诊进行比较.
- 90天的随访评估了PrEP使用,在护理中的保留,艾滋病毒风险和满意度.
主要成果:
- 只有3名参与者 (2名Iprep,1名转诊者) 在90天后服用PrEP.
- 在30,60或90天后,PrEP使用或保留在组之间没有显著差异.
- 对查的高满意度,但低兴趣和意识是障碍.
结论:
- 与转诊相比,基于ED的PrEP启动并没有改善PrEP的使用或保留.
- 对ED PrEP启动的障碍仍然存在,包括患者的意识和兴趣.
- 需要进一步的策略来克服在紧急情况下获得PrEP的障碍.
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