通过比较OCT和贝塞尔-2PM测量结果,发现了容易受到频繁停机动态的影响的毛细血管
Rockwell P Tang1, Shannon Kelley1, Gülce Küreli1
1Department of Biomedical Engineering, Boston University, Boston, Massachusetts, MA, USA.
概括
毛细血管停滞或红细胞流动停止在神经系统疾病中很常见. 两种成像方法的比较揭示了停滞检测的差异,中风将流量转移到经常停滞的毛细血管.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 医疗成像医学成像
背景情况:
- 暂时的毛细血管所扰乱的氧气输送在神经系统疾病,如阿尔茨海默氏症和中风.
- 了解毛细血管失败动态对于开发有效的治疗和预防策略至关重要.
- 需要先进的成像技术来准确测量和分析毛细血管位.
研究的目的:
- 为了比较两光子贝塞尔束显微镜 (贝塞尔-2PM) 和光学连贯性断层扫描 (OCT) 之间的毛细血管停滞测量.
- 通过使用这些成像方式,研究毛细血管停滞的时间动态.
- 了解不同的成像参数如何影响摊位的检测和表征.
主要方法:
- 在20分钟内使用Bessel-2PM和OCT在清醒,头部固定的小鼠中获得体积血管图.
- 毛细血管停滞事件分析了两种成像方法的时间动态和可重复性.
- 脑卒中对毛细血管停滞模式的影响被评估后的侮辱.
主要成果:
- 贝塞尔-2PM和OCT都发现了经常停滞的毛细血管的子群和大多数不经常停滞的毛细血管.
- 在OCT和Bessel-2PM之间的停机检测可重复性和动态上的差异归因于扫描速度和检测停机时间.
- 脑卒中诱导了转向经常停滞的毛细血管亚群的转变,直至脑卒中后的一周.
结论:
- 动态停机分析提供了对影响停机测量的生理和方法因素的见解.
- 比较像Bessel-2PM和OCT这样的成像技术对于在疾病模型中准确评估毛细血管失效至关重要.
- 了解神经疾病中的毛细血管停滞动力学可以指导治疗干预.
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