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美国俄俄州白尾鹿中SARS-CoV-2阿尔法变异的持久性

Natalie N Tarbuck, Sofya K Garushyants, Dillon S McBride

Emerging infectious diseases

|June 25, 2025

概括

在俄俄州自由散居的白尾鹿被发现携带SARS-CoV-2变种,包括阿尔法变种在最后一次人类检测后一年多. 这表明鹿有可能充当持久和流离失所的病毒谱系的储存库.

科学领域:

兽医病毒学兽医病毒学
野生动物疾病生态学野生动物疾病生态学
分子流行病学分子流行病学

背景情况:

自由活动的白尾鹿 (WTD) 对SARS-CoV-2具有很高的易感性.
了解SARS-CoV-2在野生动物群体中的演变和传播对于公共卫生至关重要.

研究的目的:

为了确定在俄俄州自由活动的白尾鹿中传播的SARS-CoV-2血统.
为了调查潜在的人到鹿和鹿到鹿的传播事件.
评估SARS-CoV-2变种在WTD种群中的持久性.

主要方法:

在俄俄州东北部从2023年1月到3月对WTD进行机会性采样.
在36个WTD样本中进行SARS-CoV-2全基因组测序.
使用松鼠谱系工具进行遗传学分析,以确定病毒谱系.

主要成果:

确定了6个SARS-CoV-2系,包括阿尔法 (B.1.1.7) 和奥米克朗 (BQ.1.1,BQ.1.1.63,BQ.1.1.67,BQ.1.23,XBB.1.5.35).
阿尔法变种在5个WTD中被检测到,这表明在俄俄州最后一次人类检测后的一年多的时间里,可能会发生人对鹿的传播事件.
来自俄俄州和宾夕法尼亚州的阿尔法变异序列的遗传相似性WTD表明鹿到鹿的传播.

结论:

白尾鹿可以感染多种和持久的SARS-CoV-2变种.
有证据表明,WTD可以维持像阿尔法这样的流离失所变种的传播.
持续监测是必要的,以监测WTD作为SARS-CoV-2的潜在储库.

关键词:

俄俄州俄俄州俄俄州是一个这就是SARS-CoV-2病毒.美国的美国.动物水库动物水库公共卫生公共卫生.病毒病毒病毒病毒.白尾鹿是一种白尾鹿.动物病是动物病.

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