相关实验视频

Updated: Sep 18, 2025

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Published on: February 8, 2018

使用癌症免疫循环相关特征对新辅助免疫疗法治疗的黑色素瘤进行剖析反应

S C M A Wijnen¹, P Dimitriadis¹, I L M Reijers¹

¹Department of Medical Oncology, Division of Molecular Oncology and Immunology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

Cancer immunology, immunotherapy : CII

|June 25, 2025

概括

免疫疗法可以改善转移性黑色素瘤的生存率,但并非所有患者都能从中受益. 这项研究发现,一些不响应者在脑中存在缺陷.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
癌症研究癌症研究

背景情况:

新辅助性抗PD-1和抗CTLA4联合治疗为转移性黑色素瘤患者提供了更好的生存率.
然而,并非所有患者都能对这种免疫疗法产生重大病理反应.
已知响应者的基线炎症特征,但缺乏对非响应的全面理解.

研究的目的:

调查黑色素瘤中对新辅助免疫疗法的不响应是否由于癌症免疫循环中的单个或多个缺陷.
确定癌症免疫循环中的特定步骤,这些步骤在没有反应的患者中受到损害.

主要方法:

在接受新辅助免疫治疗的黑色素瘤患者中,分析代表癌症免疫循环每个阶段的基因特征.
实现重大病理反应的患者和没有实现的主要病理反应的患者之间的基因表达特征的比较.
"免疫热"患者的分层,以确定具有特定分子缺陷的子组.

主要成果:

没有取得重大病理反应的患者通常表现出较低的癌症免疫循环基因特征表达.
在"免疫热"患者亚组中,确定了一组低响应者.
这个低响应子组在"向瘤指导"步骤中表现出一种特定的缺陷,其特征是CXCL9和CXCL10的表达低.

结论:

黑色素瘤中对新辅助免疫疗法的不响应可能源于癌症免疫循环中的特定缺陷.
针对"定位到瘤"的步骤,特别是通过调节CXCL9和CXCL10,为改善非响应黑色素瘤患者的治疗结果提供了一个潜在的策略.
了解这些特定的免疫循环缺陷可以指导开发更有效的组合免疫疗法.

关键词:

生物标志物生物标志物癌症 - 免疫循环免疫检查点抑制剂免疫检查点抑制剂黑色素瘤是一种黑色素瘤.有关RNA测序的RNA测序在WES WES中,您可以使用

更多相关视频

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

Predictive Immune Modeling of Solid Tumors

Predictive Immune Modeling of Solid Tumors

Published on: February 25, 2020

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...