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Updated: Jun 17, 2026

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人心器官的成熟使复杂的疾病建模和药物发现成为可能

Mark W Pocock1,2, Janice D Reid1,3, Harley R Robinson1

  • 1QIMR Berghofer, Brisbane, Queensland, Australia.

Nature cardiovascular research
|June 25, 2025
PubMed
概括

人类多能干细胞衍生的心脏器官 (hCOs) 的定向成熟增强了心肌细胞的成熟和心脏病模型. 这种多功能平台有助于心脏药物查和了解疾病机制.

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Model Approaches for Pharmacokinetic Data: Physiological Models01:15

Model Approaches for Pharmacokinetic Data: Physiological Models

Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...