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Updated: Sep 18, 2025

A Workflow for Lipid Nanoparticle LNP Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models SVEM
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优化延长释放型配方的l-tetrahydropalmatine基于体内结果,使用集成建模方法

Thi-Phuong-Dung Pham1,2, Huy Minh Dao3, Nguyen-My-Linh Pham1

  • 1Faculty of Pharmaceutics and Pharmaceutical Technology, Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hoan Kiem, Hanoi, Vietnam.

AAPS PharmSciTech
|June 25, 2025
PubMed
概括

这项研究使用计算工具优化了延长释放的l-Tetrahydropalmatine (l-THP) 配方用于成治疗. 优化的配方确保了安全性和有效性,具有可预测的开始和长时间的作用.

关键词:
在体外在体外相关性相关性.在体内结果的体内结果.设计实验的设计.l-四基帕胺是一种基于生理学的药物动力学.

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