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Updated: Sep 8, 2025

Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions
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Published on: June 28, 2018

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PURB-HOTAIR复合体调节了p53依赖的促进体特异性转录激活

Zhangchuan Xia1, Ning Kon1, Zhenyi Su1

  • 1Institute for Cancer Genetics, Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.

Nature structural & molecular biology
|June 25, 2025
PubMed
概括

研究人员发现了富含纯素的元素结合蛋白B (PURB) 作为一种新的p53核心压缩剂. 这种蛋白质与HOTAIR lncRNA和EZH2一起,调解促进器特异的p53转录抑制,为癌症调控提供了新的见解.

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