经典脏血管肌瘤中的伪皮质和微皮质类变化:一个由60个病例组成的多机构系列
Elie Tannous1, Deniz Baycelebi2, Ankur R Sangoi3
1Department of Pathology and Laboratory Medicine, Albany Medical Center, Albany, NY, USA.
Virchows Archiv : an international journal of pathology
|June 25, 2025
概括
血管瘤 (AML) 中的伪状和微状变化可以模仿其他癌症. 这些特征在缺乏脂肪的AML中更为常见,强调需要仔细诊断,特别是在活检中.
科学领域:
- 尿路病理学 尿路病理学
- 瘤病理学 癌症病理学
- 脏新生体的新生体
背景情况:
- 经典的脏血管肌脂瘤 (AML) 可以表现出类似伪毛囊和微毛囊的形态模式.
- 这些模式可能导致诊断混与细胞癌或尿路细胞癌.
- 这些不太知名的AML形态的发生率和临床意义需要进一步调查.
研究的目的:
- 为了评估伪毛囊和微毛囊类变化的发病率在古典血管瘤 (AML) 的多机构队列中.
- 确定这些形态模式与临床病理特征的关联,特别是脂肪含量.
- 强调识别这些特征对于准确诊断的重要性,并避免误诊.
主要方法:
- 对60名被诊断患有经典AML的多机构队列的回顾性分析.
- 生殖尿路病理学家审查病例,记录瘤特征,包括脂肪评估和伪毛囊/微毛囊样变化的程度.
- 奇平方测试用于评估形态模式和瘤亚型之间的关联.
主要成果:
- 在60个病例中 (19个 (32%) 发现了伪毛囊/微毛囊变化.
- 这些变化在缺乏脂肪的AML中 (57%) 与缺乏脂肪的AML相比 (7%;p < 0.001) 显著更频繁.
- 在平均11个月的随访期间,没有观察到复发或与瘤相关的死亡.
结论:
- 伪皮囊和微皮囊样变化是经典脏血管脂瘤 (AML) 中被低估的形态模式.
- 这些特征在缺乏脂肪的AML中更频繁地发生,这是诊断的关键区别.
- 识别这些模式,特别是在活检样本中,对于防止误诊至关重要,因为其他脏恶性瘤也是如此.
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