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混合生物物理与模拟皮肤导管VAD在一个收缩的左心脏内

Greg W Burgreen^1,2, James F Antaki³

¹Center for Advanced Vehicular Systems (CAVS), Mississippi State University, Starkville, MS, 39759, USA.

Cardiovascular engineering and technology

|June 25, 2025

概括

这项研究引入了一种混合生物物理联合模拟,用于评估心室辅助器件 (VAD) 在脉性心脏中. 新方法以现实的方式模拟血流动力学,改善VAD血相容性评估并减少体内测试.

科学领域:

生物医学工程生物医学工程
计算流体动力学的流体动力学.
心血管生理学心血管生理学

背景情况:

心室辅助器件 (VAD) 对于治疗心力衰竭至关重要.
目前的VAD模拟通常使用简化的稳定状态条件,忽视了心脏的脉性质.
这种简化可能导致对血液动力学和血液相容性相关不良事件的不准确预测.

研究的目的:

开发和介绍一个混合生物物理联合模拟战略.
为了切实地评估与循环相结合的脉动性心室内VADs的血流动力学.
改进VAD辅助心脏的计算建模.

主要方法:

一种混合策略,将心动力学和计算流体动力学 (CFD) 的集成参数网络 (LPN) 结合起来,用于详细的VAD血液动力学.
从生理上讲,现实的,单向合的边界条件从LPN到CFD.
模拟高速旋动力学导管作为左心室辅助装置 (LVAD).

主要成果:

在整个心脏周期中,不稳定的血液速度场的现实复制.
与双向CFD共模拟相比,实现了数量级的加快速度.
确定了持续的旋转流,不稳定的大动脉放电,以及在体周围的可变表面冲洗.

结论:

混合共模拟策略为机械循环支持器件提供了更具生理现实的评估.
这种方法补充并可能减少对广泛的体外研究的需求.
旨在通过改进VAD评估来缓解临床环境中的不良事件.

关键词:

导管是一个.计算流体动力学计算流体动力学心脏左侧的脉性心脏是可以跳动的.暂时使用的LVAD 暂时的机械循环支持.

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