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在小鼠中短期补充卵白水解剂后预防由引起的心脏毒性

Sarah Hoffman de Moraes Alencastre¹, Dalton Valentim Vassallo^1,2, Giulia Alessandra Wiggers³

¹Health Science Center of Vitória - EMESCAM, Vitória, ES, Brazil.

Cardiovascular toxicology

|June 25, 2025

概括

卵白水解剂 (EWH) 防止使用.

科学领域:

心血管科学心血管科学
毒理学毒理学毒理学
营养科学营养科学

背景情况:

暴露于 (HgCl2) 会导致氧化应激和心血管损伤.
卵白水解剂 (EWH) 显示出减轻金属诱导心血管问题的潜力.
针对急性毒性的EWH的预防作用尚未得到充分了解.

研究的目的:

评估短期EWH预处理对急性化 (HgCl2) 暴露的心脏保护功效.
评估EWH对引起的收缩功能障碍和孤立心肌中氧化应激的影响.

主要方法:

雄性Wistar大鼠被预先用EWH (1g/kg/天) 或水治疗了3天.
隔离的左心室乳头肌肉被暴露在6nM的HgCl2.
测量了收缩功能,内回应和反应性氧物种 (ROS) 水平.

主要成果:

急性HgCl2暴露显著损害了肌肉收缩功能,并减少了内反应.
经过EWH预处理,预防了HgCl2诱导的收缩功能障碍,并使对和异二醇的反应正常化.
经过EWH预处理,可以抑制由HgCl2暴露引起的ROS水平的增加.

结论:

短暂的3天EWH预处理提供了对急性暴露的显著心脏保护.
EWH 保持心脏收缩功能,防止氧化应激,证明了其潜在的治疗价值.
乙是一种有前途的功能性食品成分,可以减轻毒性对心血管的不良影响.

关键词:

有关急性暴露的急性暴露卵白的水解剂是卵白的水解剂.这是一种重金属,重金属.无机是一种无机.心肌机械学的心肌机械学

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