暴露于per-和多醇基物质与功能之间的关联以及慢性病患者的不良预后
Jiayin Wang1, Tianyun Gao1, Xiaohua Li1
1Department of Nephrology, The First Affiliated Hospital, Guangxi Medical University, Nanning, China.
Renal failure
|June 25, 2025
概括
暴露于per-和多醇基物质 (PFAS) 与慢性病 (CKD) 患者的功能恶化有关. 然而,PFAS暴露对这种成年CKD人群的死亡率没有显著影响.
科学领域:
- 环境健康科学 环境健康科学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 毒理学 毒理学 毒理学
背景情况:
- 和多醇基物质 (PFAS) 是广泛存在的环境污染物.
- 慢性病 (CKD) 影响了相当一部分成年人群.
- 环境污染物的联合暴露对CKD进展的影响需要进一步调查.
研究的目的:
- 检查单次和混合PFAS暴露与非透析CKD患者的功能之间的关联.
- 在这个患者队列中调查PFAS暴露与死亡风险之间的关系.
- 探索影响PFAS-功能关联的潜在相互作用.
主要方法:
- 来自美国国家健康和营养检查调查 (NHANES) 2003-2018年的数据分析.
- 包括1503名成年非透析CKD患者 (1-4阶段).
- 使用多变量回归模型和贝叶斯内核机器回归 (BKMR) 进行关联分析.
主要成果:
- 对PFOA,PFOS,PFNA和PFHxS的单次暴露与功能下降的增加有关.
- 对五种测量PFAS的混合暴露也与功能下降有关.
- 在PFAS暴露和死亡率之间没有发现显著的关联;建议与尿蛋白和药物使用相互作用.
结论:
- 单一和混合的PFAS暴露都与成年CKD患者的功能和进展较差有关.
- 暴露于PFAS并没有证明在研究的CKD人群中增加死亡率的统计学意义上的联系.
- 这些发现突显了环境污染物对先前存在病症的个体的影响.
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