和辅酶Q补充和心血管死亡率的性别差异来自老年人低的前性随机双盲安慰剂对照试验的结果
Urban Alehagen1, Jan Olav Aaseth2, Lutz Schomburg3
1Division of Cardiovascular Medicine, Department of Medical and Health Sciences, Linköping University, SE-581 85 Linköping, Sweden.
和辅酶Q10补充剂改善了心血管存活率,特别是在女性中. 这种组合疗法对老年人早期心血管疾病的预防有前途.
科学领域:
- 心脏病学 心脏病学
- 营养科学 营养科学
- 老年学是一门学科.
背景情况:
- 低和辅酶Q10 (CoQ10) 水平与心血管疾病 (CVD) 和氧化应激有关.
- 之前的试验表明,和CoQ10减少了低的老年人心血管疾病和死亡率.
- 这种补充剂的性别特异性益处以前尚未被探索.
研究的目的:
- 研究和CoQ10补充对心血管结果的性别特异性影响.
- 评估补充剂对心血管死亡率和风险因素的长期影响.
- 探索基线心血管疾病对治疗反应的影响.
主要方法:
- 一项为期4年的随机化安慰剂受控试验,随后在443名瑞典老年人中进行了6年的观察.
- 参与者接受了结合的酵母 (200微克/天) 和CoQ10 (200毫克/天) 或安慰剂.
- 分析包括Kaplan-Meier,ANCOVA,重复测量ANOVA和Cox回归,按性别分层.
主要成果:
- 补充剂显著降低了10年心血管死亡率,在女性中观察到的效果更大.
- 男性的吸烟,炎症,氧化应激和晚期缺血性心脏病 (IHD) 的基线率较高.
- 补充剂改善了两性内脏病患者的CV生存率,但在基线没有内脏病的女性中效果更为明显;它还减少了炎症,氧化应激,NT-proBNP,并改善了功能.
结论:
- 和CoQ10补充剂可以提高心血管生存率,特别是在女性中.
- 在男性中较高的基线心血管疾病患病率和吸烟可能解释了在女性中观察到的更大的益处.
- 这种补充策略在老年男性和女性的早期心血管疾病预防方面可能特别有效.
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