素作为慢性病中的生物标志物-系统性审查和元分析
Gabi Gazi1, Robert Cristian Cruciat1, Daniel-Corneliu Leucuta2
1Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.
Biomolecules
|June 26, 2025
概括
与健康个体相比,慢性病 (CKD) 患者的可佩 (CPP) 水平显著升高. 这种生物标志物在CKD各个阶段中显示出明显的差异,表明其在评估疾病严重程度和进展方面的潜力.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物标志物研究 生物标志物研究
- 临床化学 临床化学
背景情况:
- 慢性病 (CKD) 的诊断和严重程度评估仍然具有挑战性.
- 素 (CPP),一种潜在的生物标志物,在以前的研究中显示了不一致的结果.
- 现有研究需要对CPP在CKD中的作用进行全面评估.
研究的目的:
- 系统地审查和分析素 (CPP) 与慢性病 (CKD) 之间的关联.
- 评估CPP在CKD中的诊断价值.
- 使用KDIGO指南评估CPP水平与CKD严重程度之间的相关性.
主要方法:
- 在PubMed,EMBASE和Scopus的系统文献搜索.
- 包括根据GFR (KDOQI) 或eGFR (MDRD公式) 分类CKD的研究.
- 使用纽卡斯尔-太华尺度 (NOS) 和血清CPP水平的元分析进行质量评估.
主要成果:
- 包括7项涉及2769名参与者的研究.
- 在CKD患者和健康对照人群中显著增加CPP水平 (MD 12.975).
- 在CKD各个阶段观察到明显的CPP水平差异,包括对照组与1-2/2,3,4-5阶段以及1-2与4-5阶段的对照组.
结论:
- 慢性病患者血清中CPP水平升高表明病理学中的作用.
- 在不同CKD阶段,CPP度的差异很大.
- CPP显示出作为评估CKD严重程度和进展的有价值生物标志物的潜力.
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