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肌肉侵入性膀癌中的循环瘤DNA:对预后和治疗个性化的影响

Stamatios Katsimperis¹, Lazaros Tzelves¹, Georgios Feretzakis²

¹Second Department of Urology, National and Kapodistrian University of Athens, Sismanogleio Hospital, 15126 Athens, Greece.

|June 26, 2025

概括

循环瘤DNA (ctDNA) 提供了一种非侵入性的方法来监测肌肉侵入性膀癌 (MIBC). 这种方法有助于评估瘤负担,治疗反应和个人化癌症护理的最小残留疾病.

科学领域:

在瘤学瘤学.
分子诊断学分子诊断
基因组学就是基因组学.

背景情况:

肌肉侵入性膀癌 (MIBC) 是具有高复发率的侵袭性癌症.
目前的疗法在实时监测和个性化治疗调整方面存在局限性.
循环瘤DNA (ctDNA) 为癌症评估提供了一种新的非侵入性生物标志物.

研究的目的:

审查ctDNA在MIBC中的生物基础,检测方法和临床应用.
突出ctDNA在风险分层,监测和治疗决策中的作用.
讨论ctDNA在MIBC精密瘤学的新兴用途.

主要方法:

对MIBC中ctDNA的现有文献的审查.
从关键和正在进行的临床试验中分析数据.
检查ctDNA检测技术及其临床实用性.

主要成果:

作为评估瘤负担,治疗反应和最小残留疾病 (MRD) 的生物标志物,ctDNA显示出希望.
证据支持ctDNA在MIBC中的预后和预测价值.
新兴应用包括ctDNA引导的免疫疗法和与其他诊断数据的整合.

结论:

ctDNA可以增强MIBC中手术前风险分层和术后监测.
它促进了针对辅助和全身疗法的个性化决策.
尽管面临挑战,但ctDNA集成到临床工作流程中可以提高MIBC中的精确瘤学和患者结果.

关键词:

辅助性免疫治疗是一种辅助性免疫治疗.生物标志物生物标志物膀癌的监测膀癌的监测没有细胞的DNA DNA.在循环中的瘤DNA.液体活检活检液体活检分子诊断分子诊断分子诊断肌肉侵入性膀癌是一种肌肉侵入性膀癌.精确瘤学精确瘤学风险分层的分层是风险分层.个性化治疗个性化治疗根据瘤信息进行的测定.尿路细胞癌是什么意思

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