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压力内皮层气溶化疗 (PIPAC) 对于具有和双向意图的腹膜恶性瘤

Daniele Marrelli¹, Ludovico Carbone¹, Daniele Fusario¹

¹Unit of General Surgery, Department of Oncology, AOUS, 53100 Siena, Italy.

|June 26, 2025

概括

压力内空气化疗 (PIPAC) 在内表面恶性瘤 (PSMs) 方面表现有前途. 这种治疗是安全的,可以及时进行全身治疗,并改善生存率,特别是在双向策略中.

科学领域:

在瘤学瘤学.
手术瘤学手术瘤学
胃肠病学胃肠病学

背景情况:

腹表面恶性瘤 (PSMs) 是一个重要的治疗挑战.
压力内空气化疗 (PIPAC) 提供化学疗法直接到腹腔.
需要进一步阐明PIPAC在多模式PSM治疗中的作用.

研究的目的:

评估PIPAC在患有PSM的患者中的安全性和有效性.
评估PIPAC对整体生存和治疗策略的影响.
确定将PIPAC与其他疗法结合的可行性.

主要方法:

在2020年6月至2024年12月期间接受PIPAC的64名PSM患者的回顾性分析.
数据收集包括患者人口统计,瘤特征,PIPAC程序,不良事件和生存结果.
分析治疗意图 (双向与息) 和PIPAC会议的数量.

主要成果:

在PIPAC中,严重不良事件的发生率很低 (6.2%),平均住院时间很短 (3天).
双向治疗和多次PIPAC会议与显著改善的整体存活率有关.
在34.4%的患者中实现了转化手术,结直肠和卵巢癌显示出比胃癌更好的结果.

结论:

对于患病率低的PSM,PIPAC是一种安全有效的治疗选择.
良好的安全概况支持将其纳入双向治疗策略.
皮帕克促进了系统化疗的及时恢复,提高了多模式治疗的疗效.

关键词:

皮帕克 (PIPAC) 是一个国际组织.这是双向的双向.转换转换转换的情况地方区域化疗.作为一种新辅助治疗,新辅助治疗.腹膜转移的发生.腹膜表面的恶性瘤压缩的腹膜内喷雾剂化学疗法.

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