临床医生推遗传性基因检测在参与者在遗传性癌症的风险增加的参与者
Emerson Delacroix1,2, Sarah Austin2, John D Rice3
1Department of Health Behavior & Health Equity, University of Michigan, Ann Arbor, MI 48109, USA.
Cancers
|June 26, 2025
概括
遗传性癌症的遗传检测 (GT) 尚未得到充分利用,临床医生的建议是关键. 财务压力和高等教育与较低的推率有关,在一项针对风险人群的研究中.
科学领域:
- 医学遗传学 医学遗传学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 遗传检测 (GT) 对于治疗遗传性癌症至关重要,但在临床实践中仍未得到充分利用.
- 对于GT采用的主要障碍包括知识差距,成本和不一致的临床医生建议.
- 临床医生的建议是患者接受基因检测的重要驱动因素.
研究的目的:
- 分析与接受临床医生推基因测试 (GT) 相关的因素,在具有遗传性癌症风险增加的个体中.
- 确定影响GT推可能性的人口和临床特征.
主要方法:
- 一项调查对784名成年参与者进行了调查,他们的个人或家族病史表明有遗传性癌症风险,他们没有接受GT.
- 多变量后勤回归分析了参与者的人口统计,癌症史和收到GT的临床医生建议之间的关联.
主要成果:
- 只有14.0%的符合条件的参与者报告说,他们收到了对GT的临床医生建议.
- 较年轻的成年人,没有经济压力的人以及具有高等教育水平的个人观察到较低的推率.
- 多变量分析表明,报告没有财务压力的参与者不太可能获得GT建议 (p=0.049).
结论:
- 在临床医生主导的基因测试 (GT) 建议中存在显著的差异.
- 需要加强临床医生的GT指示教育,并实施决策支持工具.
- 系统地识别符合GT标准的个人/家庭病史患者,对于公平获取至关重要.
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