重复的COVID-19疫苗接种作为胰腺癌的预后不良因素:一个回顾性,单中心的队列研究
Makoto Abue1, Mai Mochizuki2, Rie Shibuya-Takahashi2
1Departments of Gastroenterology, Miyagi Cancer Center, Natori 981-1293, Miyagi, Japan.
Cancers
|June 26, 2025
概括
重复接种COVID-19疫苗可能会使胰腺癌的预后恶化. 与疫苗接种增加相关的较高IgG4水平与较短的存活时间和瘤中更多的免疫抑制剂相关.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 在全球范围内,COVID-19疫苗被广泛使用.
- 重复接种疫苗对癌症免疫力的影响尚未完全理解.
- 胰腺癌 (PC) 的预后不佳,需要对影响因素进行研究.
研究的目的:
- 研究重复接种COVID-19疫苗和胰腺癌预后之间的关联.
- 分析血清IgG4水平的作用,一个免疫抑制剂,与疫苗接种状态和PC结果有关.
- 探索IgG4水平,瘤免疫细胞透 (Foxp3) 和疫苗接种史之间的相关性.
主要方法:
- 在2018年1月至2023年11月期间诊断的272名PC患者的回顾性分析.
- 评估与疫苗接种状态 (包括剂量数) 相关的总生存 (OS).
- 通过ELISA测量血清总IgG4,瘤Foxp3表达和尖端特定IgG4水平.
主要成果:
- 接种了三次或更多疫苗的PC患者的整体存活时间缩短.
- 血清IgG4水平和尖端特异性IgG4随着疫苗接种次数的增加而增加.
- 较高的IgG4水平与较短的生存期和瘤组织中Foxp3+细胞的增加显著相关.
结论:
- 重复接种COVID-19疫苗可能是胰腺癌患者的负面预后因素.
- 疫苗诱导的IgG4可能会导致免疫抑制和PC的较差结果.
- 需要进一步的研究来了解疫苗接种,IgG4和癌症进展之间的机制.
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