在实验研究中使用的可卡因线索:系统审查
Eileen Brobbin1, Natalie Lowry1, Matteo Cella2
1Addictions Department, National Addiction Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, UK.
Brain sciences
|June 26, 2025
概括
线索暴露疗法 (CET) 使用各种刺激来治疗可卡因使用障碍. 本综述对可卡因线索进行了分类,但强调需要更详细的例子来提高治疗的复制性和有效性.
科学领域:
- 神经科学和行为科学 神经科学和行为科学
- 成 药物 药物 药物 药物
- 心理学 心理学 心理学
背景情况:
- 线索暴露疗法 (CET) 是可卡因物质使用障碍 (SUD) 的关键干预措施.
- CET的目的是减少与毒品有关的线索对心理和生理反应的激励影响.
- 了解研究中使用的可卡因线索的多样性对于推进CET疗效至关重要.
研究的目的:
- 系统地审查和分类在研究中使用的可卡因线索的范围.
- 在提示类型,模式和研究设计中识别共同点和变异.
- 为改善可卡因SUDCET标准化和临床翻译提供基础.
主要方法:
- 对PubMed和Web of Science数据库的系统文献审查.
- 搜索在2024年8月进行,没有时间限制,遵守PRISMA指南.
- 数据提取包括参与者的人口统计,研究设计,提示任务细节和提示示例;进行了质量评估.
主要成果:
- 从3600个已识别的文章中分析了235篇,揭示了各种各样的提示类别:图像,配件,单词,气味,声音,视频,脚本和虚拟现实.
- 研究包括各种人群 (可卡因依赖者,娱乐性,多种药物使用者,对照者),样本大小从单个病例到1974名参与者.
- 通常使用的线索包括可卡因的图像/表示,使用,装备,准备项目或关于可卡因使用的对话.
结论:
- 存在各种各样的可卡因提示类别,但复制的详细文档往往缺乏.
- 在不同研究中观察到暗示号,组合,沉浸和个性化的变化.
- 未来的研究应该专注于通过更沉浸式,个性化的刺激和更清晰的临床翻译提示文档来增强CET.
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