牙周炎和MASLD之间的相互作用:病理生理学关联和预防和治疗的可能性
Martina Juzbašić1, Matej Tomas1, Ana Petrović2
1Department of Dental Medicine, Faculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia.
Biomedicines
|June 26, 2025
概括
牙周炎可能通过共享的炎症恶化代谢功能障碍相关的脂肪性肝病 (MASLD). 本综述探讨了慢性牙疾病和MASLD之间的联系,并提出了综合治疗方法.
科学领域:
- 口腔健康和代谢疾病
- 肝病学和牙周病学
背景情况:
- 牙周炎和与代谢功能障碍相关的脂肪性肝病 (MASLD) 的全球流行率不断上升.
- MASLD,以前的非酒精性脂肪肝病 (NAFLD),现在被认为是代谢起源.
- 牙周炎是一种慢性炎症性疾病,影响着大量人口.
研究的目的:
- 审查共享的病理生理机制,将牙周炎与MASLD联系起来.
- 探索慢性牙周炎症有助于MASLD发展的假设.
- 提出多学科的方法,用于早期检测和管理这两个条件.
主要方法:
- 现有文献的叙述性审查.
- 专注于共同的机制:全身炎症,胰岛素抵抗,氧化应激.
- 关键评估将口腔炎与肝脏代谢失调联系在一起的证据.
主要成果:
- 系统性炎症,胰岛素抵抗和氧化应激是关键的共享机制.
- 慢性牙周炎症可能会积极促进MASLD的代谢失调.
- 炎症调解剂在连接口腔健康和肝脏健康方面发挥着作用.
结论:
- 牙周炎和MASLD之间存在双向关系.
- 牙周健康对于管理MASLD至关重要.
- 预防和治疗需要综合,多学科的战略.
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