通过脑肠轴的自 - 淋巴体途径和神经退行变化的进展
1Institute of Cytology and Genetics, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang 421001, China.
Biomedicines
|June 26, 2025
概括
自-溶酶体通路 (ALP) 通过肠-大脑轴影响肠道健康和神经退行. 准肠道微生物群和ALP对治疗神经退行性疾病如阿尔茨海默氏症和帕金森氏症有希望.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 自-溶酶体通路 (ALP) 对于神经元健康至关重要,清除细胞废物.
- 新兴研究强调了肠-大脑轴和ALP在神经退行性疾病中的作用.
- 以前的审查没有全面地解决ALP,肠道微生物群和神经退行之间的相互作用.
研究的目的:
- 为了阐明自 - lysosomal 途径 (ALP) 和神经退行症中的肠道微生物群之间的双向关系.
- 提供关于ALP,肠道失调和神经炎症在阿尔茨海默病,帕金森病和亨廷顿病中如何相互作用的全面概述.
主要方法:
- 一个叙述性综述,综合了临床前,临床和转化研究 (2014-2025) 的证据.
- 在PubMed和Web of Science上使用关键词进行文献搜索:自,溶酶体,肠道微生物群,神经退行,肠-大脑轴.
- 包括专注于分子机制和ALP-微生物群交叉交流的研究;不包括案例报告和未经同行评审的来源.
主要成果:
- 肠-大脑轴通过神经,免疫和代谢途径促进沟通.
- 功能失调的ALP可以导致肠道失衡,肠道失调和神经炎症,加速神经退行.
- 针对肠道微生物群和通过ALP恢复肠道屏障功能的干预措施显示出延迟神经退行性疾病进展的潜力.
结论:
- 自-溶酶体通路 (ALP) 动态调节肠-大脑通信.
- 针对微生物群的治疗方法是治疗神经退行性疾病的有希望的策略.
- 恢复ALP功能是缓解来自肠道的神经炎症和神经退行症的关键.
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