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多发性硬化症患者中神经轴突和炎症性CSF生物标志物的纵向变化,这些患者接受了干扰素β治疗

Simona Petrescu^1,2, Maria-Melania Dumitru-Martoiu^1,3, Cristina Aura Panea^1,2

¹Department of Neurology, Elias Emergency and University Hospital, 011461 Bucharest, Romania.

|June 26, 2025

概括

干扰素β治疗降低了神经丝光链 (Nf-L) 水平,但在早期多发性硬化症 (MS) 中增加了酶3样1 (CHI3L1). Nf-L和CHI3L1与MS患者的长期残疾和复发率相关.

科学领域:

神经免疫学神经免疫学
生物标志物发现发现
临床神经学临床神经学

背景情况:

大脑脊髓液 (CSF) 生物标志物神经丝轻链 (Nf-L),神经丝重链 (Nf-H) 和酶3样1 (CHI3L1) 表明多发性硬化症 (MS) 中的神经轴损伤和炎症.
这些CSF生物标志物对疾病修饰疗法 (DMT) 的纵向反应及其与早期复发性复发性MS (RRMS) 的临床和放射性结果的相关性尚未完全理解.

研究的目的:

调查干扰素β (IFN-β) 治疗对早期RRMS患者中Nf-L,Nf-H和CHI3L1的CSF水平的影响.
评估这些CSF生物标志物与IFN-β治疗后的长期临床结果和MRI活性之间的关联.

主要方法:

对14名未经治疗的RRMS患者进行了一项前性的两年观察性研究,这些患者开始IFN-β治疗.
在基线和两年后测量了CSF Nf-L,Nf-H和CHI3L1水平.
评估了临床残疾 (扩展残疾状态量表 - EDSS) 和脑MRI活动,对12名患者进行了15年的临床随访.

主要成果:

在IFN-β治疗两年后,CSF Nf-L水平显著下降 (p=0.039) 和CHI3L1水平显著增加 (p=0.001);Nf-H水平保持稳定.
基线和随访Nf-L和CHI3L1水平与复发率和长期EDSS相关.
与EDSS分数相关的NF-H水平,但与复发或MRI活动无关;观察到NF-L和MRI活动之间的正相关性趋势 (p=0.07).

结论:

在早期RRMS中,CSF生物标志物对IFN-β治疗的反应不同.
在MS中,Nf-L作为治疗反应和疾病活性的敏感指标.
CHI3L1可能反映正在进行的组织重塑和炎症,支持CSF生物标志物监测,用于个性化MS治疗策略.

关键词:

CHI3L1 的意思是生物标志物生物标志物大脑脊髓液中的脑脊液.改变疾病的疗法.干扰素ββ是一种干扰素.纵向研究是一种纵向研究.多发性硬化症多发性硬化症神经纤维重链纤维的重链.神经纤维光链的光链.

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