ангиотензин受体阻塞不会降低合成 ангиотензин II (Giapreza®) 在外科手术期间的低血压中有效性 围绕移植
Natalie Pettit1, Jamie Benken1, Benito Valdepeñas1
1Retzky College of Pharmacy, University of Illinois, Chicago, IL 60612, USA.
Biomedicines
|June 26, 2025
概括
在移植期间使用 ангиотензин II (AT2S) 在服用 ангиотензин受体阻断剂 (ARB) 的患者中是安全的. 这项研究发现没有显著的血液动力学差异,与理论上的担忧相反,支持其继续使用.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 有理论上的担忧,关于血管新生素II (AT2S) 用作血管压缩剂在移植 (KT) 患者已经在血管新生素受体抑制剂 (ARBs).
- AT2S是我们围移植管理中心的标准一线血管压缩器.
- 这项研究调查了移植前ARB使用对KT期间AT2S有效性和安全性的影响.
研究的目的:
- 评估移植前ARB对AT2S在脏移植受体中的使用的血液动力学和临床影响.
- 为了比较在接受AT2S时接受ARB和非ARB的患者之间的结果.
- 为了确定先前存在的ARB疗法是否会在KT期间改变对AT2S的反应.
主要方法:
- 单中心,回顾性队列研究.
- 纳入标准:年龄≥18岁的高血压患者接受抗高血压疗法,接受AT2S作为一线血管压缩剂周围移植.
- 对ARBs (n=22) 和非ARBs (n=43) 的患者进行比较.
主要成果:
- 在ARB和非ARB组之间的AT2S使用总持续时间中没有发现显著差异.
- 系统血压 (SBP) <120 mmHg的频率和持续时间在各组之间没有显著差异.
- 需要额外的血管压缩剂支持,住院/ICU的长度,安全性和不良事件在两个队列中都相似.
结论:
- 在移植前使用ARB并没有导致在移植期间需要AT2S的患者显著不良的血液动力学或临床结果.
- 这些发现与其他冲击群体的理论担忧和观察相矛盾.
- 这项研究支持继续使用AT2S作为KT患者的第一线血管压缩剂,无论移植前的ARB治疗如何.
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