植物化学品对动物健康和生产的潜在表观遗传影响:连接证据线
Sebastian P Schreiber1, Juan Villalba1, Mirella L Meyer-Ficca2
1Department of Wildland Resources, Utah State University, Logan, UT 84322, USA.
Animals : an open access journal from MDPI
|June 26, 2025
概括
植物化学物质,植物化合物,通过表观遗传修饰为反动物提供健康益处. 这些潜在的遗传性变化会影响基因表达,影响后代的发育和畜牧业.
科学领域:
- 动物营养 动物营养
- 分子遗传学 分子遗传学
- 植物化学 植物化学
背景情况:
- 植物化学物质,植物衍生化合物,对人类和牲畜具有显著的健康益处.
- 虽然它们被称为抗氧化剂,但它们更广泛的健康影响,包括抗炎和免疫调节作用,与表观遗传过程有关.
- 食动物通过食用多样化,富含植物化学物质的植物来自我治疗.
研究的目的:
- 探索植物化学物质在通过反动物的表观遗传机制调节基因表达中的作用.
- 研究继承性表观遗传变化的影响,如胎儿编程,在反动物营养.
- 弥合植物二级化学,反动物营养和分子 (epi) 遗传学之间的知识差距.
主要方法:
- 对人类,动物和新兴反动物研究现有证据的审查.
- 分析植物化学物质如何与染色质修饰剂相互作用以影响基因表达.
- 在营养干预下探索在反动物中遗传性表观遗传适应的潜力.
主要成果:
- 植物化学物质可以通过改变染色体修饰剂活性来调节基因表达.
- 由植物化学物质诱导的表观遗传修饰可能是遗传的.
- 胎儿编程和其他可遗传的表观遗传变化可能在接受营养干预的反动物中很常见.
结论:
- 植物化学物质通过表观遗传机制对反动物产生健康益处.
- 可遗传的表观遗传变化,包括胎儿编程,对畜牧业的繁殖和生长效率有重大影响.
- 需要进一步的研究才能充分理解这些相互作用及其应用.
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