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对Litopenaeus vannamei的急性水暴露的有毒影响:生存,生理反应,转录组和肠道微生物群
Xinghui Luo1, Jian Chen1,2, Asare Derrick1
1College of Fisheries, Guangdong Ocean University, Zhanjiang 524088, China.
Animals : an open access journal from MDPI
|June 26, 2025
概括
在 (Litopenaeus vannamei) 中过多的 (Se) 暴露会导致肝损伤,氧化应激和亡. 还破坏肠道微生物群,改变基因表达,影响的健康和水产养殖.
科学领域:
- 水生物质毒理学研究
- 环境科学环境科学
- 海洋生物学 海洋生物学
背景情况:
- 过多的 (Se) 对水生动物构成毒性风险.
- 关于养殖水中的Se毒性的全面研究是有限的.
- 了解Se对的影响对于水产养殖的可持续性至关重要.
研究的目的:
- 为了研究 (Se) 对太平洋白,Litopenaeus vannamei.暴露的有毒影响.
- 评估Se对病原学,氧化应激,免疫,亡,基因表达和肠道微生物群的影响.
- 为了确定L. vannamei. 的Se的毒性值.
主要方法:
- 急性毒性测试以确定L. vannamei. 的Se的96小时LC50的L. vannamei.
- 在72小时内将暴露在不同度的Se中 (0,0.01xLC50,0.1xLC50).
- 评估组织病理学,氧化应激标志物,免疫酶活动,细胞亡,转录组形状和肠道微生物群.
主要成果:
- 暴露于Se导致肝损伤 (真空化,) 和诱导亡 (增加卡斯帕-3,减少Bcl-2).
- 氧化应激标志物 (ROS,SOD,PO,GSH-PX) 增加,而免疫酶活动 (LYS,AKP,ACP) 增加.
- 转录组分析揭示了显著的基因表达变化,肠道微生物群分析显示多样性减少,Vibrio和Acinetobacter数量增加.
结论:
- 暴露会在Litopenaeus vannamei中引发显著的毒性影响,包括器官损伤,氧化应激和免疫反应.
- 它破坏了的肠道微生物群结构,并导致转录水平的代谢障碍.
- 这些发现凸显了污染对健康和水产养殖实践的有害影响.
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