在儿科患者的冷保存大动脉同位素移植替代:一个单一中心的经验与中期随访
Mustafa Kemal Avşar1, Yasin Güzel1, Barış Kırat2
1Department of Cardiovascular Surgery, Faculty of Medicine, Çukurova University, 01330 Adana, Türkiye.
Children (Basel, Switzerland)
|June 26, 2025
概括
低温保存的大动脉同体移植对于儿科大动脉和根部置换是安全有效的,表现出良好的早期和中期功能. 由于潜在的晚期并发症,长期监测至关重要.
科学领域:
- 心血管外科心血管外科
- 儿童心脏病学 儿童心脏病学
- 生物材料在医学中的应用
背景情况:
- 在儿科患者中,大动脉和根置换带来了独特的挑战.
- 冷保存的大动脉同移植为重建提供了一个生物选择.
- 在这个年轻人群中评估结果对于手术决策至关重要.
研究的目的:
- 评估冷保存的大动脉同位移植植入儿科患者的早期和中期结果.
- 在大动脉和根部置换后分析并发症,死亡率和移植功能.
主要方法:
- 对36名接受同种植植植的儿科患者 (2至7岁) 的回顾性分析.
- 标准的根部置换技术与中度低温心肺旁路术.
- 评估早期并发症,死亡率,心声回声和移植性能,长达7年.
主要成果:
- 没有30天死亡率;在3年后有一个晚期死亡率 (2.8%).
- 7年后,由于根动脉瘤和严重吐,进行了两次重复手术 (5.6%).
- 满意的早期血液动力学 (平均梯度8.4 ± 3.2 mmHg);92.9%的移植功能在5年.
结论:
- 冷保存的同体移植是一种安全有效的选择,用于儿科大动脉和根部置换在早期到中期的随访.
- 长期监测对于管理结构退化或根扩张等潜在并发症至关重要.
- 未来的进展,如脱细胞化移植,可能会提高长期的耐用性和整合性.
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