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患有神经性膀的儿童的抗氧化剂状况
Joanna Bagińska-Chyży1, Agata Korzeniecka-Kozerska1
1Department of Pediatrics and Nephrology, Medical University of Białystok, 17 Waszyngton Str., 15-274 Białystok, Poland.
Children (Basel, Switzerland)
|June 26, 2025
概括
儿童神经性膀与抗氧化剂水平的改变有关,血清总抗氧化剂状态 (TAS) 较低,尿液TAS较高. 这种不平衡可能会导致这些患者的膀功能受损.
科学领域:
- 生物化学 生物化学
- 儿科泌尿外科 儿科泌尿外科
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 儿科神经性膀 (NB) 显著影响膀功能,通常是源于骨髓瘤.
- 氧化应激是一种抗氧化防御的失衡,与各种病理状况有关.
研究的目的:
- 评估儿科神经性膀 (NB) 患者的总抗氧化剂状态 (TAS).
- 评估NB对尿路抗氧化剂的影响.
- 在NB患者中,将抗氧化剂状态与尿动力学参数相关联.
主要方法:
- 与29名NB患者和57名非NB对照进行了比较.
- 测量血清和尿液TAS (正常化为肌素),功能标志物和尿动力学发现.
- 使用色度测量ABTS方法来确定TAS.
主要成果:
- 与对照组相比,NB患者的血清TAS显著降低,尿液TAS和UTAS/肌素比率升高 (p < 0.001).
- 在最大囊泡测量容量时,在UTAS/肌氨酸和排毒器压力之间发现了正相关性.
- 在UTAS/肌素和膀壁遵守之间观察到负相关性.
结论:
- 在NB患者中,血清TAS降低和尿液TAS增加表明抗氧化剂平衡失衡.
- 这种不平衡可能在儿科神经性膀中尿动力学功能的恶化中起作用.
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