参与过敏性肠道炎病理生理学的免疫机制
Jimena Pérez-Moreno1, Esther Bernaldo-de-Quirós2, Mar Tolín Hernani1
1Servicio de Pediatria, Digestivo Infantil, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.
Children (Basel, Switzerland)
|June 26, 2025
概括
婴儿非IgE介导的过敏性口腔炎涉及天生的免疫力,而不是T细胞. 增加的NK16+56-细胞和埃索诺菲尔可能是这种牛奶过敏的关键生物标志物.
科学领域:
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
- 过敏研究 研究过敏
背景情况:
- 非IgE介导的牛奶过敏的潜在机制,特别是食物蛋白诱导的过敏性直肠炎 (FPIAP),仍然在很大程度上是未知的.
- 以前的研究表明T细胞介导的途径,但研究结果不一致.
研究的目的:
- 调查FPIAP的免疫基础.
- 专门研究调节性T细胞 (Tregs) 在FPIAP病理生理学中的作用.
主要方法:
- 一项前性观察性研究,涉及诊断为FPIAP的婴儿和健康婴儿的对照组.
- 通过流细胞计在急性 (T0) 和分辨率 (Tres) 阶段分析周围血液淋巴细胞群,包括Tregs.
主要成果:
- 与健康对照人群相比,患有急性FPIAP的婴儿表现出更高的T-CD4记忆细胞数量,更多的调节性B细胞,以及更高的Tregs百分比.
- 在FPIAP组中观察到显著增加的颗粒细胞 (主要是乙素),树突细胞 (mDC2) 和NK16+56细胞.
- ROC曲线分析表明NK16+56-细胞和粒细胞是FPIAP和健康婴儿之间的潜在歧视因素.
结论:
- FPIAP的病理生理学似乎与先天性免疫有关,而不是T细胞介导的机制.
- 升高的NK16+56-细胞,埃索诺菲尔和树突细胞与FPIAP有关.
- 这些先天性免疫细胞需要进一步研究,作为非IgE介导牛奶蛋白过敏的潜在生物标志物.
更多相关视频
08:37Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
Published on: April 21, 2015
16.8K
10:39Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
Published on: April 16, 2019
7.8K
相关概念视频
01:26Asthma-II: Pathophysiology and Classification
2.9K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.9K
01:27Allergic Drug Reactions
1.0K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.0K
01:20Asthma: Pathogenesis and Management
618
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
618
02:06Allergic Reactions
29.0K
Overview
29.0K
01:17Gastritis-II: Pathophysiology
601
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
601
01:28Inflammatory Response
8.5K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
8.5K