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在多次注射肉毒素后,脑麻儿童的运动功能的变化:一个病例报告

Nancy Lennon1, Chris Church1, Jose J Salazar-Torres1

  • 1Department of Orthopaedics, Nemours Children's Health, 1600 Rockland Rd., Wilmington, DE 19803, USA.

Children (Basel, Switzerland)
|June 26, 2025
PubMed
概括

这项研究追踪了一名患有性双性脑 (CP) 的儿童,持续了七年. 在A型肉毒素 (BoNT-A) 注射后,运动功能和步态的下降需要进一步调查.

关键词:
波托克斯 (Botox) 是一种治疗方法.脑性麻 脑性麻 是一种步态 步态 步态 步态机动功能 机动功能 机动功能性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性等.

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Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...
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