针对老年高尿血症男性早期认知障碍的非侵入性查,使用跨色编码双重超声波
Zhirong Xu1, Jiayi Ye2, Han Wang1
1Department of Ultrasound, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China.
Diagnostics (Basel, Switzerland)
|June 26, 2025
概括
穿色编码双重声谱可以通过检测心室扩大和后脑动脉脉动力的增加来识别患有高尿血的老年男性的轻度认知障碍. 这种非侵入性工具有助于风险人群的早期查.
科学领域:
- 神经学 神经学
- 老年病的医生 老年病的医生
- 血管医学 血管医学
背景情况:
- 超血与认知能力下降有关,但大脑结构和血液动力学变化尚未得到充分理解.
- 早期发现轻度认知障碍 (MCI) 对老年人群的及时干预至关重要.
研究的目的:
- 为了评估跨骨彩色编码双重声 (TCCD) 声谱作为MCI的非侵入性查工具在老年男性高尿血.
- 评估MCI和没有MCI的高尿血症男性的大脑结构和血液动力学标志物.
主要方法:
- 一项涉及195名60岁以上高尿血症男性的横截面研究,根据蒙特利尔认知评估 (MoCA) 评分分层.
- TCCD测量了第三腹腔宽度 (TVW),脑动脉脉动度指数 (PI) 和脑动脉中部 (MCA) 和后部 (PCA) 的电阻指数 (RI).
- 接收器操作特征 (ROC) 曲线和内核密度图用于评估诊断性能.
主要成果:
- 与MCI (HUA + MCI) 组相比,高尿血症 (HUA + MCI) 组的血清尿酸较高,TVW较大,左侧PCA RI和PI较高,与仅高尿血症 (HUA) 组相比.
- 左PCA脉动性指数 (PI) 被确定为MCI最具特异性的标志物 (AUC = 0.701,特异性为90.6%).
- 通过核密度图表证实了关键参数的明显分布.
结论:
- 检测到TCCD的心室扩大和PCA脉动率升高是区分MCI在高尿血症男性的准确指标.
- 在风险人群中,TCCD提供了一种非侵入性,可访问和高度特定的方法,用于早期查MCI.
- TCCD可以补充现有的神经成像和认知评估,用于早期发现MCI.
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