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微RNA对心脏病的影响

Marco Antonio Cordeiro¹, Ana Elisa T S de Carvalho¹, Regina Celia Spadari¹

¹Laboratory of Stress Biology, Department of Biosciences, Health and Society Institute, Campus Baixada Santista, Federal University of Sao Paulo (UNIFESP), Santos 11020-015, SP, Brazil.

International journal of molecular sciences

|June 26, 2025

概括

微RNAs (miRNAs) 调节心脏中的基因表达,并与心血管疾病 (CVD) 有关. 它们在血液中的检测表明它们有可能成为心脏病的非侵入性生物标志物.

科学领域:

分子生物学分子生物学
心脏病学心脏病学
遗传学是一个遗传学.

背景情况:

心血管疾病 (CVD) 是全球主要的死亡原因,需要对其分子基础进行研究.
微RNAs (miRNAs),小型非编码RNAs,调节信使RNA (mRNA) 的稳定性和蛋白质翻译,影响细胞过程.
miRNAs在心血管功能中发挥关键作用,影响心肌细胞,内皮细胞,光滑肌细胞和纤维细胞.

研究的目的:

审查有关miRNAs参与心脏发育和心血管疾病的现有文献.
探索miRNAs作为心血管疾病的非侵入性生物标志物的潜力.

主要方法:

在心血管环境中调查miRNA的研究的综合文献综述.
分析与心脏发育和疾病状态有关的miRNA表达模式.

主要成果:

miRNAs是心脏发育和功能的关键调节者.
在患有各种心血管疾病的患者的血液中观察到改变miRNA表达.
miRNAs参与调节心血管系统内的信号通路和细胞通信.

结论:

血液中的miRNA表达对心血管疾病的非侵入性诊断和预后应用具有前景.
向miRNA调节为治疗心脏病提供了潜在的治疗策略.
对miRNA机制的进一步研究可以为心血管医学开辟新的途径.

关键词:

心血管疾病 (CVD) 是一种心血管疾病.表观遗传学的机制表观遗传学的机制心灵的心灵心灵的心灵心灵的心灵微型RNAs (miRNAs) 是一种微型RNA.

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相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...