辐射促进急性和慢性损伤脂肪组织.
Kia T Liermann-Wooldrik1, Elizabeth A Kosmacek1, Joshua A McDowell1
1Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
International journal of molecular sciences
|June 26, 2025
概括
放射治疗会损害脂肪细胞,导致氧化应激,炎症和代谢功能障碍. 这种慢性损伤可能会加剧治疗毒性和癌症进展,突出显示脂肪组织保护的必要性.
科学领域:
- 在瘤学瘤学.
- 代谢科学 代谢科学
- 辐射生物学 辐射生物学
背景情况:
- 放射治疗是癌症治疗的基石,但它对脂肪组织的影响尚不清楚.
- 脂肪组织经常暴露在辐射中,但其损伤和长期后果在很大程度上仍未被阐明.
- 现有的关于辐射对脂肪组织影响的研究通常涉及全身辐射,而不是临床相关的剂量.
研究的目的:
- 为了研究临床相关的辐射剂量后脂肪细胞的急性和持续性损伤.
- 为了阐明辐射暴露后脂肪组织中的分子和细胞变化.
- 探索辐射诱导的脂肪组织功能障碍和癌症进展之间的潜在联系.
主要方法:
- 在体外和体外实验中使用脂肪细胞和动物模型进行实验.
- 评估活性氧物种 (ROS),脂质过氧化和脂解活性.
- RNA测序用于分析基因表达变化,重点关注衰老和炎症途径.
- 辐射后1个月和6个月免疫细胞透 (巨细胞,T细胞) 的体内分析.
主要成果:
- 与对照细胞相比,受辐射的脂肪细胞呈现出增加的ROS,脂质过氧化和脂解.
- RNA测序揭示了辐射脂肪组织中衰老和炎症途径的上调.
- 在体内模型显示,在辐射暴露1个月和6个月后,脂肪组织中巨细胞和T细胞的积累增加.
- 观察到的辐射脂肪组织的变化与肥胖中观察到的变化相似,肥胖是已知的癌症驱动因素.
结论:
- 临床相关的辐射剂量会诱导脂肪细胞的严重急性和慢性损伤.
- 辐射暴露会引发氧化应激,代谢功能障碍,炎症和脂肪组织的衰老.
- 在放射治疗期间保护脂肪组织可以减轻治疗毒性,并可能减少癌症复发和进展.
相关概念视频
Mutations
40.4K
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
40.4K
Biological Effects of Radiation
16.1K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
16.1K
Hypodermis
5.5K
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
5.5K
Obesity
627
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
627
External Anatomy of the Kidney
1.7K
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
1.7K
Cholesterol: Significance and Regulation
698
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
698


