在患有扩散大B细胞淋巴瘤的患者中,细胞外膀的形状和静脉血栓栓塞的风险
Vladimir Otasevic1,2, Charlotte Gran3, Natasa Milic4
1Lymphoma Center, Clinic for Hematology, University Clinical Center of Serbia, 11000 Belgrade, Serbia.
International journal of molecular sciences
|June 26, 2025
概括
与健康个体相比,扩散性大B细胞淋巴瘤 (DLBCL) 患者表现出明显的细胞外囊泡 (EV) 概况. 然而,这些EV变化与静脉血栓塞栓症 (VTE) 风险或DLBCL患者的整体存活率无关.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 生物化学 生物化学
背景情况:
- 血栓,特别是静脉血栓塞栓症 (VTE),是癌症患者的重要并发症,特别是那些患有攻击性淋巴瘤的癌症患者,如扩散性大B细胞淋巴瘤 (DLBCL).
- 细胞外囊泡 (EVs) 正在成为VTE的潜在生物标志物,促使人们对它们在DLBCL相关血栓形成中的作用进行调查.
研究的目的:
- 在患有扩散性大B细胞淋巴瘤 (DLBCL) 的患者中研究细胞外囊泡 (EV) 的概况.
- 确定特定的EV群体与DLBCL患者静脉血栓栓塞 (VTE) 和整体存活率 (OS) 的风险之间的关联.
主要方法:
- 一项前性队列研究,涉及62名DLBCL患者和健康对照.
- 分析各种EV种群,包括血小板衍生的EV (PEV),E-选择蛋白+EV,P-选择蛋白+EV和表达组织因子 (TF) 的EV,使用流细胞计.
- 使用考克斯回归分析来评估与VTE和OS的相关性.
主要成果:
- 与健康对照组相比,DLBCL患者的PEVs,E-selectin+ EVs,P-selectin+ EVs和几个表达TF的EVs度显著更高.
- 与对照组相比,DLBCL患者的TF-PEV度明显较低.
- 在有或没有VTE的DLBCL患者之间没有发现EV度的显著差异,也没有任何EV群体与整体存活率相关.
结论:
- 与健康个体相比,DLBCL患者呈现出独特的细胞外囊泡 (EV) 形状,其特点是特定的EV子集的水平较高.
- 在DLBCL患者中确定的EV概况与发生静脉血栓塞栓症 (VTE) 的风险或整体生存结果没有显著关联.
- 需要进一步的研究,以充分理解DLBCL中这些独特的EV配置文件的含义.
相关概念视频
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
42
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
42
Overview of Exosomes
2.9K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.9K
Lymphatic Vessels and Lymph Transport
12.2K
Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
12.2K


