代谢功能障碍相关的稳态性肝病的发病和临床管理
Roxana Liana Lucaciu1, Sorina Cezara Coste2, Adriana Corina Hangan3
1Department of Pharmaceutical Biochemistry and Clinical Laboratory, Faculty of Pharmacy, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
International journal of molecular sciences
|June 26, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的全球健康问题. 本综述涵盖了MASLD的发病,诊断和新兴治疗方法,强调了需要多学科护理和新疗法的需要.
科学领域:
- 肝病学和胃肠病学 肝病学和胃肠学
- 代谢和内分泌系统疾病
- 药理学和药物开发领域
背景情况:
- 代谢功能障碍相关的脂肪性肝病 (MASLD) 是一种进展性慢性肝病,具有重大全球健康影响.
- MASLD是一种复杂的多系统性疾病,需要多学科的患者护理方法.
- 目前的治疗策略旨在减少肝硬化,纤维化和炎症.
研究的目的:
- 提供有关MASLD病原体,诊断方法和当前治疗选择的最新概述.
- 讨论 MASLD 患者当代的临床管理.
- 预测MASLD的未来治疗进展和药物批准.
主要方法:
- 关于MASLD的最新研究的文献综述.
- 对MASLD药物疗法的正在进行的临床试验的分析.
- 综合有关MASLD诊断和患者管理协议的信息.
主要成果:
- MASLD的发病因子是多因素的,涉及代谢和炎症途径.
- 诊断方法包括非侵入性成像和生物标志物评估.
- 几种新型药理学药物正在临床试验的后期阶段,显示出治疗MASLD的前景.
结论:
- 有效管理MASLD需要一个全面的,多学科的战略.
- 在不久的将来,预计将为MASLD带来新的,已批准的药理疗法.
- 持续的研究对于理解和对抗MASLD的进展至关重要.
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