皮质衍生细胞外囊在过敏敏感化中的作用:系统性审查
William Browne1, Georgina Hopkins1, Stella Cochrane2
1School of Life Sciences, University of Nottingham, Nottingham NG7 2RD, UK.
International journal of molecular sciences
|June 26, 2025
概括
皮质细胞释放细胞外囊泡 (EVs),可以促进或防止IgE介导的过敏敏感化. 研究表明,它们的作用因上皮屏障而异,凸显了进一步研究的必要性.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 过敏研究 研究过敏
背景情况:
- 从上皮质衍生的细胞外囊泡 (EVs) 越来越多地被认为是它们在细胞间通信中的作用.
- 它们在免疫球蛋白E (IgE) 介导的过敏敏感化中的特定参与仍然是积极研究的领域.
研究的目的:
- 系统地审查现有关于表皮质衍生的EVs在IgE介导过敏敏感化中的作用的文献.
- 综合有关EV介导过敏免疫反应的机制和结果的现有证据.
主要方法:
- 在EMBASE,Web of Science和PubMed进行了系统的文献搜索.
- 包括的研究是原始的临床和研究文章,重点是表皮质衍生的EV和IgE介导的过敏敏感化.
- 不包括非IgE介导的过敏,摘要和评论文章.
主要成果:
- 18个出版物表明,上皮质衍生的EV可以促进过敏敏感性或耐受性.
- EVs可能会诱导T助手2 (Th2) 极化或T调节 (Treg) 细胞诱导.
- EVs的效果似乎取决于屏障:肠上皮质促进耐受性,而鼻和支气管上皮质显示混合效应;皮肤上皮质没有研究.
结论:
- 皮质衍生的EV在调节IgE介导的过敏敏感性方面发挥着重要作用.
- 需要对所有上皮屏障进行进一步的研究,利用人体体外试验模型和临床研究,以充分阐明它们的功能.
更多相关视频
06:39Author Spotlight: Accelerating Research on Bacterial Extracellular Vesicles Separation and Heterogeneity
Published on: September 1, 2023
3.2K
09:18Isolation of Extracellular Vesicles from Murine Bronchoalveolar Lavage Fluid Using an Ultrafiltration Centrifugation Technique
Published on: November 9, 2018
9.7K
相关概念视频
Allergic Reactions
29.0K
Overview
29.0K
Allergic Drug Reactions
1.0K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.0K
Overview of Exosomes
2.9K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.9K
Asthma-II: Pathophysiology and Classification
2.9K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.9K
Cross-reactivity
31.5K
Overview
31.5K
Antibody Structure
61.4K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
61.4K
