基于金属的纳米粒子对心血管有毒性
Eun-Hye Kim1, Sehyeon Park2, Ok-Nam Bae2
1College of Pharmacy, Kyungsung University, Busan 48434, Republic of Korea.
International journal of molecular sciences
|June 26, 2025
概括
基于金属的纳米颗粒 (MNP) 的暴露正在增加,可能会损害心血管系统. 本综述详细介绍了MNP如何通过各种机制引起心血管毒性,影响心脏和血管健康.
科学领域:
- 纳米技术和环境健康
- 心血管毒理学心血管毒理学
- 纳米医学的安全性
背景情况:
- 通过吸入,摄入和皮肤接触增加人类对金属纳米颗粒 (MNP) 的暴露.
- 人们越来越担心MNP的潜在健康影响,因为它们具有独特的纳米特征.
- MNPs可以从暴露部位转移到循环系统,并在体内积累.
研究的目的:
- 审查MNP引起的心血管毒性.
- 突出MNP生物分布,细胞毒性机制和对心血管疾病的病理影响.
- 综合最近关于MNP心血管影响的体外和体内发现.
主要方法:
- 文献综述侧重于MNP心血管毒性.
- 对研究MNP生物分布和积累的研究进行分析.
- 检查心血管细胞中细胞毒性机制 (氧化应激,亡,铁亡) 的研究.
- 包括体外和体内研究.
主要成果:
- 许多MNP会破坏内皮功能,并促进氧化应激.
- 在心血管细胞中,MNP会诱导细胞亡和铁亡.
- 增加内皮通透性,降低血脑屏障完整性和增强的血凝剂活性有助于血管和心脏功能障碍.
- 在毒性中MNP和释放的金属离子的协同作用.
结论:
- 许多MNP对心血管系统构成重大风险.
- 了解MNP诱导的心血管毒性对公共健康至关重要.
- 需要进一步的研究来阐明MNP心血管影响的全部范围.
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