身体周长和认知功能:阿波利波蛋白E ε4在老年人中的作用
Ji-Hyun Kim1, Young Min Choe1,2, Hye Ji Choi1
1Department of Neuropsychiatry, Hallym University Dongtan Sacred Heart Hospital, Hwaseong 18450, Gyeonggi, Republic of Korea.
International journal of molecular sciences
|June 26, 2025
概括
像中臂周长 (MAC) 和小腿周长 (CC) 这样的肌肉测量与老年人的认知表现有关. 这些关联在没有阿波利波蛋白E ε4等位基因 (APOE4) 的个体中更强.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 营养科学 营养科学
背景情况:
- 认知能力下降是老年人群日益关注的一个问题.
- 身体构成,特别是肌肉质量在认知健康中的作用需要进一步调查.
- 阿波利波蛋白E ε4基因 (APOE4) 状态是认知障碍的已知危险因素.
研究的目的:
- 研究中臂周长 (MAC) 和小腿周长 (CC) 与认知表现之间的关系.
- 检查阿波利波蛋白E ε4等位基因 (APOE4) 状态对这些关联的缓和作用.
- 探索上肢和下肢肌肉测量在认知功能中的不同作用.
主要方法:
- 分析了196名老年人 (65-90岁) 在一般生活方式和AD (GLAD) 研究中的数据.
- 使用CERAD神经心理电池评估认知表现,以情节性记忆得分 (EMS) 和非记忆得分 (NMS) 为结果.
- 进行了多次线性回归分析,包括与APOE4状态的相互作用效应.
主要成果:
- 更高的MAC与更好的情节性记忆 (EMS) 相相关,而更高的CC与更好的非记忆认知 (NMS) 相相关 (P_B <0.0125).
- 这些关联在APOE4阴性个体中是显著的,但在APOE4阳性个体中并非如此.
- 腰围 (WC) 与认知指标没有关联.
结论:
- 上肢和下肢肌肉质量可能会对认知领域产生不同的影响,MAC与情节性记忆相关,CC与非记忆认知相关.
- 维持肌肉健康可能是维护认知功能的策略,特别是在APOE4阴性老年人中.
- 这些发现有助于理解身体健康和认知衰老之间的相互作用.
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