一座桥太远吗? 对于临床非功能性垂体瘤的医学疗法
Nikita Mogar1, Dongyun Zhang1, Anthony P Heaney1,2
1UCLA Department of Medicine, Los Angeles, CA 90095, USA.
International journal of molecular sciences
|June 26, 2025
概括
临床非功能性垂体瘤 (CNFPTs) 的医疗疗法显示出有限的疗效. 虽然体静止素受体连接体和多巴胺激动剂提供了一些瘤缩,但需要新的治疗方法来更好地管理CNFPT.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 神经外科 神经外科
背景情况:
- 临床非功能性垂体瘤 (CNFPTs) 在诊断时通常很大并且具有侵入性.
- 手术切除通常是不完整的,放射疗法 (RT) 携带诸如下垂体等风险.
- 目前对CNFPTs的医疗疗法有不一致的结果,突出了对有效治疗的未满足需求.
研究的目的:
- 审查临床非功能性垂体瘤 (CNFPTs) 的医疗疗法的疗效.
- 根据已发表的文献,确定当前的治疗选择并评估它们的结果.
主要方法:
- 使用PubMed数据库进行了全面的文献搜索.
- 从1982年1月到2024年7月发表的文章重点关注CNFPTs的医疗治疗.
- 分析了瘤对体静止素受体连接体 (SRL),多巴胺D2受体激动剂和其他药物的反应数据.
主要成果:
- 在111名CNFPT患者中,Somatostatin受体连接体 (SRLs) 在28%的患者中实现了瘤缩.
- 在355名患者中,多巴胺激动剂治疗导致32%的瘤缩,51%的瘤稳定,55%的瘤增长.
- 还检查了不太常见的疗法,如GnRH类似物,PRRT和temozolomide的疗效.
结论:
- 现有的CNFPTs的医学疗法,包括SRL和多巴胺激动剂,显示出有限的疗效.
- 对CNFPTs的新,安全和有效的医疗治疗有很大的需求.
- 强大的随机化安慰剂对照临床试验对于推进CNFPT管理至关重要.
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