相关实验视频
Updated: Sep 18, 2025

05:34
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
Published on: April 4, 2025
871
末期病患者的抗凝剂:一个批判性审查
Fnu Parul1,2, Tanya Ratnani1,3, Sachin Subramani1,4
1PearResearch, Dehradun 248001, India.
Healthcare (Basel, Switzerland)
|June 26, 2025
概括
在慢性病 (CKD) 和末期病 (ESRD) 中使用抗凝剂是复杂的,因为有出血和凝血风险. 谨慎的剂量和监测是必不可少的,需要更好的临床指导方针.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性病 (CKD) 和末期病 (ESRD) 呈现出复杂的静血失衡,增加了血栓和出血风险.
- 这使抗凝剂治疗复杂化,并强调需要基于证据的临床指导.
研究的目的:
- 批判性地审查关于CKD和ESRD抗凝剂治疗的当前文献.
- 强调改变的药理动力学,临床并发症和必要的治疗调整.
主要方法:
- 使用PubMed,Scopus和谷歌学者进行了全面的文献搜索.
- 包括对CKD/ESRD群体抗凝剂安全性,有效性和药理动学的研究,重点是肝素,LMWH,华法林和DOACs.
主要成果:
- 慢性脏病/ESRD患者具有高凝血状态,血栓和出血风险增加.
- 抗凝剂的管理需要剂量调整 (例如LMWH,华法林) 和仔细考虑药理动力学.
- 直接口服抗凝剂 (DOAC),如阿皮克萨班,显示出希望,但对其他CKD的数据有限.
结论:
- 在CKD/ESRD中,抗凝血是具有挑战性的,因为凝血和药理动学的变化.
- 个性化,以患者为中心的方法与明智的剂量和监测至关重要.
- 需要进一步进行高质量的随机对照试验,以建立最终的指南.
相关概念视频
Acute Kidney Injury IV: Diagnostic Studies and Prevention
64
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
64
Venous Thrombosis III: Interprofessional Care
28
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
28
Chronic Kidney Disease III: Interprofessional Care
84
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
84
Continuous Renal Replacement Therapy
156
Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
156
Anticoagulant Drugs: Low-Molecular-Weight Heparins
924
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
924
Acute Kidney Injury V: Interprofessional Care
51
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
51

