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口腔下粘膜纤维化分子基因组学:叙述性审查

Vasileios Zisis¹, Stefanos Zisis², Christina Charisi¹

¹Department of Oral Medicine/Pathology, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

|June 26, 2025

概括

本综述探讨了口腔下粘膜纤维化 (OSMF) 的分子基因组学,这是一种与阿雷卡坚果和烟草使用相关的慢性疾病. 关键的基因和蛋白质,如TGF-β和MUC1,都与它的发展有关.

科学领域:

基因组学就是基因组学.
分子生物学分子生物学
口腔医学是指口腔医学.

背景情况:

口腔下粘膜纤维化 (OSMF) 是一种渐进的口腔粘膜纤维化.
与阿雷卡坚果和烟草使用有关,导致显著的发病率.
人们对OSMF的分子遗传机制知之甚少.

研究的目的:

研究口腔下粘膜纤维化 (OSMF) 的分子基因组学.
分析过去十年的相关文献.
确定OSMF病变发生过程中的关键分子参与者.

主要方法:

在2015-2025年期间的MEDLINE (PubMed) 的文献搜索.
关键词:分子基因组学和口腔下粘膜纤维化.
手动搜索和参考检查相关的物品.

主要成果:

综述中包括了12篇文章.
确定了关键分子:TGF-β,Wnt抑制因子-1,CypA,HSP-70 1B,卡尔雷蒂库林,Lumican,Enolase 1,MMP-2,IGF-1R,XIST,Epigallocatechin-3-gallate,Von Hippel-Lindau,以及MUC1和4. 发现了一些关键分子:TGF-β,Wnt抑制因子-1,CypA,HSP-70 1B,Calreticulin,Lumican,Enolase 1,MMP-2,IGF-1R,XIST,Epigallocatechin-3-gallate,Von Hippel-Lindau,以及MUC1和4.
这些分子在OSMF分子相互作用中至关重要.

结论:

了解OSMF分子病原体需要检查分子相互作用和蛋白质作用.
先进的基因组技术为OSMF提供了新的研究途径.
跨学科的方法可能会为OSMF管理带来新的治疗策略.

关键词:

基因组学就是基因组学.口腔癌是指口腔癌的发生.口腔损伤口腔损伤的发生口腔潜在的恶性疾病.在口腔癌前期的癌症.在口腔下粘膜纤维化.蛋白质组学蛋白质组学

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