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豆蛋白通过肠道微生物群重塑改善肝脏代谢平衡

Kaining Han¹, Zhuoyao Deng², Guangxin Feng²

¹School of Medicine, Sun Yat-sen University, Guangzhou 510275, China.

Foods (Basel, Switzerland)

|June 26, 2025

概括

豆蛋白,包括原生 (MPI) 和热变质 (DMPI) 形式,通过改变肠道细菌及其代谢物来改善肝脏健康. 这种植物蛋白质来源支持新陈代谢平衡,并减少炎症.

科学领域:

营养科学营养科学
微生物学微生物学
代谢学代谢学代谢学

背景情况:

植物蛋白提供健康益处,豆蛋白成为主要来源.
豆蛋白的生物功能性质,特别是它对肝脏代谢的影响,需要进一步研究.

研究的目的:

在小鼠中评估食豆蛋白分离物 (MPI和DMPI) 的肝脏代谢调节效应.
了解肠道微生物群及其代谢物在调解这些影响中的作用.

主要方法:

鼠模型被食含有原生豆蛋白分离物 (MPI) 或热变质豆蛋白分离物 (DMPI) 的饮食.
分析了肠道微生物组合,血清脂质概况,肠道炎症标志物和代谢物水平 (SCFA,胆汁酸,醇衍生物).

主要成果:

两种MPI和DMPI都恢复了肝脏代谢平衡,由生物活性微生物代谢产物介导.
MPI和DMPI调节了肠道微生物群的组成,MPI促进Bifidobacterium和DMPI促进Lachnospiraceae_NK4A136_group.
这两种形式都增加了像Faecalibaculum这样的有益细菌,降低了血清总胆固醇,在高脂肪饮食模型中缓解了肠道炎症,与增加的SCFA和恢复的代谢概况有关.

结论:

食豆蛋白,在原生和变质的形式,促进肝脏代谢的好处.
这些好处是通过肠道微生物群的重塑和微生物代谢输出的调节来实现的,突出显示了豆蛋白在代谢健康方面的潜力.

关键词:

消化能力消化能力我们的肠道微生物群.肝脏代谢性恒常化代谢产物的代谢产物蒙格豆蛋白质 (Mung Bean Protein) 是一种豆类蛋白质.

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