与非阻塞性冠状动脉 (ANOCA) 结节炎的治疗方法:系统性审查和元分析
Fabienne E Vervaat1, Annemiek de Vos1, Jimmy Schenk2
1Department of Cardiology, Catharina Hospital, 5623 EJ Eindhoven, The Netherlands.
Journal of clinical medicine
|June 26, 2025
概括
非阻塞性冠状动脉 (ANOCA) 的心痛影响许多患者,但治疗的有效性各不相同. 本综述强调了大多数疗法对心痛频率的改善,尽管需要更多的研究来确定ANOCA特定的疗效.
科学领域:
- 心脏病学 心脏病学
- 临床医学 临床医学
- 基于证据的医学基于证据的医学.
背景情况:
- 高达40%的心痛患者没有阻塞性冠状动脉疾病 (ANOCA).
- ANOCA显著降低了生活质量,增加了心肌梗塞和死亡的风险.
- 尽管进行了最佳的医疗治疗,但症状持续影响约25%的ANOCA患者,对量身定制治疗的知识有限.
研究的目的:
- 为临床医生提供ANOCA目前治疗模式的疗效概述.
- 系统地审查和对ANOCA治疗的随机对照和队列研究进行元分析.
主要方法:
- 搜索了PubMed/MEDLINE,Embase,Cochrane图书馆和临床试验的注册表. 在这些注册表中搜索了PubMed/MEDLINE,Cochrane图书馆和临床试验的注册表.
- 包括ANOCA治疗方式的随机对照和队列研究.
- 主要结局:胸痛频率的变化;次要结局:运动能力,生活质量,CCS类,CFR和生存率.
主要成果:
- 包括80项研究;只有10项符合目前的ANOCA定义.
- 在大多数治疗中观察到心痛频率的显著改善.
- 神经调节 (-3.35 SMD),三甲 (-1.74 SMD) 和中国传统医学 (-1.55 SMD) 显示出显著的疗效.
结论:
- 大多数评估的治疗方式在ANOCA患者中显著改善了胸痛频率.
- 由于符合ANOCA定义的研究数量有限,必须谨慎解释结果.
- 进一步的研究至关重要,以确定专门针对ANOCA的现有治疗方法的疗效.
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