在SARS-CoV-2住院患者中,脂聚糖结合蛋白 (LBP) 和炎症生物标志物
Aldanah Alshathri1, Iman Bindayel1, Wajude Alabdullatif1
1Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia.
Journal of clinical medicine
|June 26, 2025
概括
临界和非临界的COVID-19患者之间,脂聚糖结蛋白 (LBP) 水平没有差异. 然而,LBP与炎症性细胞因子相关,这表明在严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染中免疫反应和营养不良的作用.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 感染导致严重的炎症和免疫失调.
- 脂多糖结合蛋白 (LBP) 调节天生的免疫系统.
- 了解免疫反应对于管理病毒大流行至关重要.
研究的目的:
- 在SARS-CoV-2患者中评估LBP和炎症生物标志物的血水平.
- 研究LBP,炎症性细胞因子,营养不良状态和疾病严重程度之间的关系.
主要方法:
- 对166名SARS-CoV-2患者 (80名危急,86名非危急) 的横截面研究.
- 收集病史,人体测量,生化数据和血样本.
- 使用营养风险查-2002 (NRS-2002) 工具进行营养风险评估.
主要成果:
- 在关键和非关键SARS-CoV-2患者之间的LBP水平没有显著差异.
- 腰血压水平与IL-10,TNF-α和IL-6/IL-10比率有显著的相关性 (p < 0.001).
- 在住院的SARS-CoV-2患者中证实了炎症性细胞因子的升高.
结论:
- 炎症性细胞因子与SARS-CoV-2的严重程度和营养不良有关.
- 研究结果表明,肠道炎症在SARS-CoV-2病变发生过程中起着作用.
- 针对疾病管理的炎症生物标志物的新干预措施的潜力.
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